HPV vaccination urgent necessity due to the severe increase of STDs in Western countries. Its efficiency is supported by a recent study. The rate of STDs continues to rise in developed countries. One of these is caused by human papillomavirus (HPV), only in the US, 80% of sexually active men and women are infected at some point in their lives (National Foundation for Infectious Diseases, January 14, 2020).
Vaccination current efficacy
A review of 26 randomized controlled trials shows that giving the vaccine to preteen and teenage girls before they become sexually active will protect them from genital warts and HPV-related precancers that show up on PAP screening (read more HERE). In this respect, our Observatory published an article in BMC Medical Ethics entitled Ethical considerations of universal vaccination against human papillomavirus(April 7, 2014), encouraging universal vaccination with the previous consent of parents (see our List of Published Articles).
HPV few vaccinations warn health care authorities
While HPV vaccination rates continue to rise in the United States, researchers say most young people there are still not receiving the vaccine, and that more has to be done to encourage parents to vaccinate their children (read HERE).
A brief article published on the WHO website, entitled Major milestone reached as 100 countries have introduced the HPV vaccine into national schedule, gives a worldwide overview of the introduction of the vaccine in countries around the world today, with updated interactive maps.
Why HPV few vaccinations when they are universally offered? Perhaps the fear to vaccinate children or the lack of risks’ information
In this respect, the latest study, and perhaps the largest one, was published today in the New England Journal of Medicine. The study presents new evidence confirming the efficacy of vaccination (read HERE). The novelty of this study is that it provides data to inform the relationship between quadrivalent HPV vaccination and the subsequent risk of invasive cervical cancer (high-grade cervical lesions) which were lacking in previous papers. The medical definition of invasive cervical cancer is “Cancer that has spread from the surface of the cervix to tissue deeper in the cervix or to other parts of the body.” (Medicinet by William C. Shiel Jr., MD, FACP, FACR).
We excerpt from the aforementioned study some of what we consider to be the more interesting points:
The authors say “We used nationwide Swedish demographic and health registers to follow an open population of 1,672,983 girls and women who were 10 to 30 years of age from 2006 through 2017. We assessed the association between HPV vaccination and the risk of invasive cervical cancer, controlling for age at follow-up, calendar year, county of residence, and parental characteristics, including education, household income, mother’s country of birth, and maternal disease history.”
They continue, “During the study period, we evaluated girls and women for cervical cancer until their 31st birthday. Cervical cancer was diagnosed in 19 women who had received the quadrivalent HPV vaccine and in 538 women who had not received the vaccine. The cumulative incidence of cervical cancer was 47 cases per 100,000 persons among women who had been vaccinated and 94 cases per 100,000 persons among those who had not been vaccinated. After adjustment for age at follow-up, the incidence rate ratio for the comparison of the vaccinated population with the unvaccinated population was 0.51 (95% confidence interval [CI], 0.32 to 0.82). After additional adjustment for other covariates, the incidence rate ratio was 0.37 (95% CI, 0.21 to 0.57). After adjustment for all covariates, the incidence rate ratio was 0.12 (95% CI, 0.00 to 0.34) among women who had been vaccinated before the age of 17 years and 0.47 (95% CI, 0.27 to 0.75) among women who had been vaccinated at the age of 17 to 30 years.”
As stated in the above study:
- 1.7 million women aged 10 to 30 years were followed.
- 500,000 were vaccinated against HPV
- 19 vaccinated women were diagnosed with cervical cancer
- 538 unvaccinated women were diagnosed with cervical cancer
Conclusion of the study
They conclude “Among Swedish girls and women 10 to 30 years old, quadrivalent HPV vaccination was associated with a substantially reduced risk of invasive cervical cancer at the population level. (Funded by the Swedish Foundation for Strategic Research and others.)”
Study coauthor Par Sparen, also of the Karolinska Institute said in a statement that, “HPV vaccination may significantly reduce the risk of cervical cancer, especially if completed at an early age. Our data strongly supports continuing HPV vaccinations of children and adolescents through national vaccination programs.” (read HERE). This study should be known by parents to encourage vaccination to fight HIV few vaccinations.
In the coronavirus crisis, the prevention campaigns are difficult to implement due to the lack of health professionals but health care authorities treat to resolve the issue with new measures to facilitate the vaccination. In this respect, FDA has raised the recommendation of HPV vaccination to 45 (January 14, 2020). Health care experts say that it is good news to women and men who did not receive the vaccine before. Another news is that a new vaccine has been approved by FDA which appears to be more effective.