Immune response in pregnant women vaccinated with mRNA vaccines
In a previous special report (read HERE), we referred to the advisability of COVID-19 vaccination for pregnant women. Very briefly, we concluded that, in general, American gynecologists do not see any particular problems with vaccination in this group. In contrast, British gynecologists are in favor of pregnant women waiting until after the pregnancy to get vaccinated, unless they have objective risk factors due to their healthcare or social work or have a previous medical condition that could predispose them to COVID-19.
A case report published last month in BMC Pediatrics (read HERE) reported the first known case of an infant with SARS-CoV-2 IgG antibodies detectable in cord blood after maternal vaccination.
COVID-19 mRNA vaccines induce a robust immune response in pregnant women, which they transmit to their children if they are breastfed
A study published the same month in the American Journal of Obstetrics and Gynecology (read HERE), authored by several researchers from various medical institutions in Boston (US), supports these findings. It included 131 women who had been vaccinated (84 pregnant, 31 lactating and 16 non-pregnant controls). Levels of antibodies to SARS-CoV-1 were measured in pregnant and lactating women (who breastfed their children). The assessment was carried out 2 to 6 weeks after the second dose of the vaccine. Antibody levels in the umbilical cord were determined at delivery.
The results showed that antibody levels were similar in pregnant, lactating, and non-pregnant women. All antibody levels were higher than those of women who had had COVID-19 during the pregnancy.
Robust immune response in pregnant women vaccinated with mRNA vaccines
The authors concluded that COVID-19 mRNA vaccines induce a robust immune response in pregnant women, which they transmit to their children if they are breastfed, and that this response is superior to that achieved with natural immunity. These data support the advisability of vaccinating pregnant women with mRNA COVID-19 vaccines (read HERE).