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CRISPR gene editing has evolved over the past decade from an experimental tool to a therapeutic platform with clinical trials in multiple areas: hematology, oncology, and rare, infectious, and metabolic diseases. In 2025, over 65 clinical trials evaluated CRISPR technologies or base editors to treat human diseases. One of these led to the development of CasgevyTM—approved for the treatment of sickle …
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Two recent research papers published in Science and PNAS have reignited the debate on Down syndrome, gene editing, and the ethical limits of biomedical research. While one of the studies analyzed the molecular alterations in fetal brain development in fetuses with trisomy 21 obtained after induced abortions, the other explored silencing of the extra chromosome 21 found in this syndrome using CRISPR-Cas9 technology. Although …
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The possibility of genetically modifying human beings no longer belongs solely to the realm of science fiction. Rapid advances in gene-editing techniques such as CRISPR have generated intense scientific, ethical, and social debate about the limits of intervention in human nature, especially considering the development of applications aimed not only at curing diseases but also at enhancing physical and cognitive …
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Would we have been able to understand the universe today without Albert Einstein's intuition? Inspired by a captivating science fiction premise—an alien civilization capable of interstellar travel yet entirely ignorant of relativity—this article explores Einstein’s singular contribution to the history of science. The Theory of General Relativity arose not from a mere accumulation of experimental data, but from a remarkable …
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