One problem in reprogramming adult cells, using the technique proposed by Yamanaka in 2006, is that the percentage of cells reprogrammed is low, and not all are reprogrammed at the same time. Now, it appears that this problem has been resolved, after Israeli scientists developed a method that allows practically 100% of the cells to be reprogrammed within a week, and furthermore, all at the same time. In order to achieve this, they only had to silence a single gene, Mbd3, which is apparently responsible for counteracting pluripotence (Nature, DOI: 10.1038/nature 12587, 2013).


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