Lung transplant new possibilities suggest recent findings.

Millions of people worldwide suffer from severe and irreversible lung diseases that require lung transplants, but this cannot always be done due to a lack of available organs. Current bioengineering therapies to regenerate these organs are unable to replicate the extraordinary cellular diversity and complex three-dimensional structures needed for gas exchange in the lungs.

Producing artificial lungs

To find a solution to this problem, a recent article describes the successful generation of functional lungs in mice. through a blastocyst complementation approach that replaces the missing lung tissue in mice without lungs, and how new lung tissue can be developed in them using mouse iPS cells. The mice produced survived to adulthood and their lungs functioned the same as those of normal mice, according to the authors. Confirming the lung transplant new possibilities that open an avenue for transplants in humans.

These results could pave the way to producing artificial lungs in larger animals that could be used in the future in human medicine, a practice that would not, in principle, entail any ethical difficulty, since iPS cells would be used to produce them.