Last Friday Circulation Journal published an article with an international study of the Center for Applied Medical Research (Cima) and the University of Navarra Clinic (Pamplona Spain) in which reports the identification of the heart cells responsible for repairing the damage that occurred in the heart after an attack. The researchers say “These “repair” cells are a subpopulation of cardiac fibroblasts that play a fundamental role in the generation of the collagen scar necessary to prevent the rupture of the ventricular wall, and the research also reveals the molecular mechanisms involved in the activation of these cells and in regulating its function.”
The authors concluded “We report cardiac fibroblasts CF – cells that produce connective tissue – heterogeneity, their dynamics during the course of myocardium infarct and redefine the CF that respond to cardiac injury and participate in myocardial remodeling. Our study identifies Cthrc1 as a novel regulator of the healing scar process, and as a target for future translational studies.”
The finding provides new resources for heart treatments and gives to the pharmaceutical researchers relevant information to enhance the proper medications after a heart attack. In this respect, the advances in cell therapies could also help develop new treatments in this field. From a bioethical point of view, this hopeful news could lower the significant number of deaths due to heart attacks in all age groups.
Read more about heart cells therapies experimentation in animals (HERE)